Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water.
History
Adapalene was approved in 1996 by the FDA for use in the treatment of acne.
Available forms
Adapalene is available in four different forms: gel, solution, pledglets and cream.
Indications
Adapalene is indicated for acne vulgaris.
Pharmacodynamics
Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.
Pharmacokinetics
Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.
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