Lichen sclerosus et atrophicus (LSA) is a rare skin disease. Its causes are poorly understood, but it is unlikely to have an infectious etiology. Autoimmunity is one possible cause. When it occurs on the vulva, it leads in 1-4 % of cases to vulvar carcinoma .
Histologically there's hyperkeratosis, atrophic epidermis , sclerosis of dermis and lymphocyte activity in dermis.
See also